Taking these seven types of medicine may cause constipation

Few people have never suffered from constipation. There are many reasons for constipation. In addition to digestive system diseases, diet, and mental factors, drug-induced constipation is also very common. Drug-induced constipation refers to the decrease in the frequency of bowel movements due to the use of drugs, or the lack of smooth, laborious, dry stools and small amounts of stools. The common drugs that easily cause constipation mainly include the following categories, friends must pay more attention.

Opioids: morphine, fentanyl, codeine, methadone, etc. Mainly reduce intestinal peristalsis and delay the transit time of intestinal contents in the intestine; some substances can reduce the secretion of intestinal fluid and increase the absorption of part of the intestinal water and electrolytes; opioids increase the absorption surface area of ​​intestinal villi and increase the absorption of liquid The absorption of feces will cause the stool to become dry; it will also delay the emptying of the stomach and cause gastroparesis. The above conditions can cause constipation.

Non-steroidal anti-inflammatory drugs: ibuprofen, naproxen, indomethacin, indomethacin, etc. It mainly inhibits mucus secretion, makes the intestine dry, and loses lubrication on the surface of stool, causing constipation.

Diuretic antihypertensive drugs: such as thiazides. It can cause dehydration of the body, allowing excess fluid to be absorbed from the colon. Central antihypertensive drugs such as clonidine can stimulate the intestinal nerves, increase the absorption of fluids and electrolytes, limit the secretion of digestive juices, and cause constipation.

Irritating laxatives: castor oil, phenolphthalein, rhubarb, rectal suppositories, etc. Long-term use will reduce rectal reflex and cause delayed constipation, which can be reversed after stopping the drug. Long-term use of irritating laxatives may also cause black colon disease and aggravate constipation.

Anticholinergic drugs: tricyclic antidepressants (such as amitriptyline, doxepin), monoamine oxidase inhibitors, antipsychotic drugs (such as clozapine, phenothiazines), antiparkinsonian drugs (Bromocriptine), antispasmodics (atropine, anisodamine), etc. These drugs will reduce intestinal motility, prolong the transit time in the intestines, and may cause severe intestinal obstruction.

Some metal-containing preparations: barium sulfate, ferrous sulfate, calcium carbonate, etc. This type of medicine will combine with inabsorbable substances in the intestinal tract to form insoluble solids, causing the stool to become hard and difficult to pass.

Chemotherapy drugs: vincristine, cyclophosphamide, etc. Such drugs can damage the enteric nervous system and autonomic nervous system, affect the intestinal mucosa, and cause diarrhea or constipation.

For drug-induced constipation, the following measures can be taken: 1. If the constipation is severe, you should seek medical treatment as soon as possible, and adjust the medication plan according to the doctor's advice to minimize the side effects; 2. For the symptoms of constipation, perform general treatment. Ensure adequate water, fiber and physical exercise; 3. If it is fecal block embolism, you can enema or use rectal suppositories, or oral laxatives; 4. Massage can also be used as an auxiliary treatment.

In order to prevent the occurrence of constipation, it is necessary to develop good living habits and bowel habits, maintain adequate water intake, 1500~2500ml daily; increase dietary fiber, such as fruits, vegetables, oats, corn, soybeans, etc., can improve Stool traits and bowel habits; proper physical exercise, especially the exercise of the abdominal muscles, is conducive to the recovery of gastrointestinal function. Finally, it is reminded that when using laxatives, the dosage should be adjusted appropriately to achieve a laxative effect. Generally, it only takes a few days and should not be abused.